erythropoietin receptor การใช้

• High level erythropoietin receptor expression is localized to erythroid progenitor cells.
• Defects in the erythropoietin receptor may produce erythrocytosis.
• In general, the defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis.
• The drug stimulates erythropoiesis by interacting with the erythropoietin receptor on progenitor cells in the bone marrow.
• Precursors of red cells, the proerythroblasts and basophilic erythroblasts also express erythropoietin receptor and are therefore affected by it.
• Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor.
• The burst-forming unit-erythroid ( BFU-E ) cells start erythropoietin receptor expression and are sensitive to erythropoietin.
• In many families, PFCP is due to an autosomal dominant mutation in the " EPOR " erythropoietin receptor gene.
• Second-place finisher and silver medalist Davide Rebellin later tested positive for Continuous erythropoietin receptor activator, causing the IOC to strip him of his silver medal.
• Loss of function of the erythropoietin receptor or JAK2 in mice cells causes failure in erythropoiesis, so production of red blood cells in embryos and growth is disrupted.
• Subsequent stage, the colony-forming unit-erythroid ( CFU-E ), expresses maximal erythropoietin receptor density and is completely dependent on erythropoietin for further differentiation.
• However, the possibility that erythropoietin may be neuroprotective is inconsistent with the poor transport of the chemical into the brain and the low levels of erythropoietin receptors expressed on neuronal cells.
• As a postdoctoral fellow at the Whitehead Institute of Biomedical Research in Cambridge, Massachusetts, D'Andrea cloned the erythropoietin receptor, a protein known to rescue red blood cell progenitors from apoptosis.
• In the bloodstream, red cells themselves do not express erythropoietin receptor, so cannot respond to EPO . However, indirect dependence of red cell longevity in the blood on plasma erythropoietin levels has been reported, a process termed neocytolysis.
• The eukaryotic molybdopterin binding domain is currently found in only five other human genes, xanthine dehydrogenase, sulfite oxidase ( mitochondrial precursor ), aldehyde oxidase, erythropoietin receptor precursor and the ATPbinding cassette, sub-family A, member 2 ( ABCA2 ).
• From studies on rats and mice, researchers have found that satellite glial cells express many neurotransmitter receptors, such as muscarinic acetylcholine and erythropoietin receptors . and different S-100 proteins, the most useful marker available today for SGC identification is glutamine synthetase ( GS ).
• M鋘tyranta had primary familial and congenital polycythemia ( PFCP ) causing an increase in red blood cell mass and hemoglobin due to a mutation in the erythropoietin receptor ( EPOR ) gene, which was identified following a DNA study done on over 200 members of his family, as reported in 1993.
• Cells at the CFU-e stage express some erythropoietin receptor ( EpoR ), and thus can be induced to terminally differentiate in vitro in 2 3 days in the presence of only erythropoietin ( Epo ) ( together with the basic contents of culture media : FBS, BSA in IMDM ).
• Di Luca  who had previously served a fifteen-month suspension after testing positive for continuous erythropoietin receptor activator ( CERA ) at the 2009 Giro d'Italia  himself expressed his " surprise " at the positive test, while race director Michele Acquarone angrily chastised Di Luca at a press conference, describing him as " stupid ".
• His research group was the first to clone and sequence mRNAs encoding a mammalian glucose transport protein, GLUT1, and then GLUT2 and the insulin-responsive GLUT4, an anion exchange protein, a transporter for free fatty acids, the hepatic asialoglycoprotein receptors, intestinal sucrose-isomaltase, the erythropoietin receptor, two subunits of the TGF?receptor, and several adipocyte-specific proteins including adiponectin ( formerly Acrp30 ).